Our Genetics teams are using high-throughput sequencing to combine the testing for rare bleeding, platelet and thrombosis disorders into a single workflow. The Haemophilia and Thrombosis Genetics team currently offer full gene Sanger sequencing and variant analysis for the F7, F8, F9, F10, F11, SERPINC1 (Antithrombin) and PROC genes. Targeted Sanger sequencing and variant analysis …

Abstract – Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection. IgG to the Spike protein …

Abstract IgG antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, essential for IgG function, shows variable composition in humans. Afucosylated IgG variants are already used in anti-cancer therapeutic antibodies for their elevated activity through Fc receptors (FcγRIIIa). Here, we report that afucosylated IgG (~6% of total …